Article
Early peanut introduction wins over the HLA-DQA1*01:02 allele in the interplay between environment and genetics.
The Journal of clinical investigation - 4 Jan 2022
Manohar Monali, Nadeau Kari Christine, Kasowski Maya
Abstract excerpt
The rising incidence of food allergy in children underscores the importance of environmental exposures; however, genetic factors play a major role. How the environment and genetics interact to cause food allergy remains unclear. The landmark Learning Early About Peanut Allergy (LEAP) clinical trial established that early peanut introduction protects high-risk infants, consistent with the tolerizing effects of gut...
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