Article
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.
Nature communications - 24 Feb 2015
Hong Xiumei, Hao Ke, Ladd-Acosta Christine, Hansen Kasper D, Tsai Hui-Ju, Liu Xin, Xu Xin, Thornton Timothy A, Caruso Deanna, Keet Corinne A, Sun Yifei, Wang Guoying, Luo Wei, Kumar Rajesh, Fuleihan Ramsay, Singh Anne Marie, Kim Jennifer S, Story Rachel E, Gupta Ruchi S, Gao Peisong, Chen Zhu, Walker Sheila O, Bartell Tami R, Beaty Terri H, Fallin M Daniele, Schleimer Robert, Holt Patrick G, Nadeau Kari Christine, Wood Robert A, Pongracic Jacqueline A, Weeks Daniel E, Wang Xiaobin
Abstract excerpt
Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at...
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