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Article

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2026

Chen Hongrui, Huang Zening, Chang Rui, Gao Wei, Qiu Yajing, Sun Bin, Hua Chen, Lin Xiaoxi

Abstract excerpt

PIK3CA mutations drive benign adipose overgrowth in facial infiltrating lipomatosis (FIL), but the downstream molecular mechanisms remain incompletely understood. This study investigated the role of palmitoyl-protein thioesterase 1 (PPT1)-mediated depalmitoylation in regulating aberrant adipogenesis induced by mutant PIK3CA. Using single-cell RNA-seq, molecular dynamics simulations, and functional assays in...

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Share to Adipogenesis
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to E1A-Associated p300 Protein

Share to Lipoylation

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Share to Thiolester Hydrolases

Source

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Identifiers

PMID: 41610323
DOI: 10.1002/advs.202523139
PMCID: PMC13045223

Genes

PIK3CA
PPT1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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