Article
Transient SUMOylation Inhibition In Human Pre-adipocytes Stably Imprints a Transcriptional Beiging Fate
2025-03-11
Abstract excerpt
SUMOylation regulates chromatin states and transcriptional programs that preserve cellular identity, yet how transient perturbation of the SUMO pathway impacts adipocyte plasticity remains unclear. Here we show that brief pharmacologic inhibition of SUMO conjugation in human pre-adipocytes using TAK-981 primes stable de novo beige differentiation in the presence of the PPARG agonist rosiglitazone. Transient TAK-98...
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Identifiers and source
- Literature Corpus work
- e1ffe49b-8514-5708-afde-10ab512b0811
- DOI
- 10.1101/2025.03.07.642034