Article

PTEN regulates adipocyte progenitor growth, differentiation and replicative aging

2021-01-07

Abstract excerpt

The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates the insulin signaling pathway. Germline PTEN pathogenic variants cause PTEN Hamartoma Tumor Syndrome (PHTS), associated with lipoma development in children. It remains unclear which mechanisms trigger this aberrant adipose tissue growth. Adipocyte progenitor cells (APCs) lose their capacity to differentiate into adipocytes during conti...

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Literature Corpus work: 975d135b-bda9-5912-a06f-24be2bf8834e
DOI: 10.1101/2021.01.05.425433

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