Article

“Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity”

2025-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Congenital generalized lipodystrophy type 2 (CGL2) is caused by mutations in the BSCL2 gene, which encodes the protein seipin. However, how seipin loss causes adipose tissue failure remains unclear. Using human adipocyte progenitor cells capable of robust differentiation in vitro and in vivo, we reveal two unexpected findings that redefine CGL2 pathogenesis. First, seipin is dispensable for lip...

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Literature Corpus work: b799eb97-07de-50eb-975c-f5f12623fcd1
DOI: 10.1101/2025.11.09.687445

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