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Article

Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2020

Liu Xiaorong, Chen Jianhan

Abstract excerpt

Intrinsically disordered proteins (IDPs) are important functional proteins, and their deregulation are linked to numerous human diseases including cancers. Understanding how disease-associated mutations or drug molecules can perturb the sequence-disordered ensemble-function-disease relationship of IDPs remains challenging, because it requires detailed characterization of the heterogeneous structural ensembles of...

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PMID: 31797597
PMCID: PMC6934143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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