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Mechanistic insight into the destabilization of p53TD tetramer by cancer-related R337H mutation: a molecular dynamics study.

Physical chemistry chemical physics : PCCP - 23 Feb 2022

Yu Yawei, Dong Xuewei, Tang Yiming, Li Le, Wei Guanghong

Abstract excerpt

The p53 protein is a tumor suppressor crucial for cell cycle and genome integrity. In a very large proportion of human cancers, p53 is frequently inactivated by mutations located in its DNA-binding domain (DBD). Some experimental studies reported that the inherited R337H mutation located in the p53 tetramerization domain (p53TD) can also result in destabilization of the p53 protein, and consequently lead to an...

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PMID: 35166747
DOI: 10.1039/d1cp05670k

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