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Article

Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.

PloS one - 1 Jan 2011

Barakat Khaled, Issack Bilkiss B, Stepanova Maria, Tuszynski Jack

Abstract excerpt

BACKGROUND: The protein p53 plays an active role in the regulation of cell cycle. In about half of human cancers, the protein is inactivated by mutations located primarily in its DNA-binding domain. Interestingly, a number of these mutations possess temperature-induced DNA-binding characteristics. A striking example is the mutation of Arg248 into glutamine or tryptophan. These mutants are defective for binding to...

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Identifiers

PMID: 22110706
DOI: 10.1371/journal.pone.0027651
PMCID: PMC3218007

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Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.PMID 22110706Read ↗

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