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Article

Elucidating the Mechanisms of R248Q Mutation-Enhanced p53 Aggregation and Its Inhibition by Resveratrol.

The journal of physical chemistry. B - 14 Sept 2023

Liu Qian, Li Le, Yu Yawei, Wei Guanghong

Abstract excerpt

Aggregation of p53 mutants can result in loss-of-function, gain-of-function, and dominant-negative effects that contribute to tumor growth. Revealing the mechanisms underlying mutation-enhanced p53 aggregation and dissecting how small molecule inhibitors prevent the conversion of p53 into aggregation-primed conformations are fundamentally important for the development of novel therapeutics for p53...

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PMID: 37665658
DOI: 10.1021/acs.jpcb.3c04700

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