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Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study

29 Apr 2025

Abstract excerpt

BACKGROUND: Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types and in East Asian individuals with different Lp(a) genetic architecture is uncertain. METHODS: We measured plasma levels of Lp(a) in a nested case-control study of 18 174 adults (mean [SD] age, 57 [10]...

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Atherosclerosis and Cardiovascular Diseases
Diabetes, Cardiovascular Risks, and Lipoproteins
Lipoproteins and Cardiovascular Health

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40297899
DOI: 10.1161/circulationaha.124.072086

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