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Article

Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure.

The Journal of biological chemistry - 30 Mar 2012

Wang Ranran, Li Qing, Helfer Christine M, Jiao Jing, You Jianxin

Abstract excerpt

Chromatin structure organization is crucial for regulating many fundamental cellular processes. However, the molecular mechanism that regulates the assembly of higher-order chromatin structure remains poorly understood. In this study, we demonstrate that Brd4 (bromodomain-containing protein 4) protein participates in the maintenance of the higher-order chromatin structure. Brd4, a member of the BET family of...

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Identifiers

PMID: 22334664
DOI: 10.1074/jbc.M111.323493
PMCID: PMC3322821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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