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Pediatric and Adolescent/Young Adult High-Grade Gliomas With Adult-Type Molecular Features.

Pathology international - 1 Jan 2026

Singh Jyotsna, Bhardwaj Supriya, Singh Swati, Mansoori Shabnam, Vasant Srinidhi, Srivastava Kirti, Kedia Shweta, Garg Ajay, Suri Ashish, Sharma Mehar Chand, Sarkar Chitra, Suri Vaishali

Abstract excerpt

High-grade gliomas (HGGs) in pediatric and adolescent/young adult (AYA) patients are biologically heterogeneous. Most exhibit pediatric-type molecular features, but a subset shows adult-type DNA methylation profiles with distinct diagnostic and therapeutic implications. We retrospectively analyzed 60 consecutive HGG, NOS cases in patients aged 0-39 years. Genome-wide DNA methylation profiling was performed using...

Topics

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Biomarkers, Tumor
Brain Neoplasms
Child, Preschool
DNA Methylation
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Isocitrate Dehydrogenase

Source

Identifiers

PMID: 41589343
DOI: 10.1111/pin.70087

Genes

BRAF
MGMT
NF1
PTEN
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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