Article
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Neuro-oncology - 5 Sept 2024
Nussbaumer Gunther, Benesch Martin, Grabovska Yura, Mackay Alan, Castel David, Grill Jacques, Alonso Marta M, Antonelli Manila, Bailey Simon, Baugh Joshua N, Biassoni Veronica, Blattner-Johnson Mirjam, Broniscer Alberto, Carai Andrea, Colafati Giovanna Stefania, Colditz Niclas, Corbacioglu Selim, Crampsie Shauna, Entz-Werle Natacha, Eyrich Matthias, Friker Lea L, Frühwald Michael C, Garrè Maria Luisa, Gerber Nicolas U, Giangaspero Felice, Gil-da-Costa Maria J, Graf Norbert, Hargrave Darren, Hauser Peter, Herrlinger Ulrich, Hoffmann Marion, Hulleman Esther, Izquierdo Elisa, Jacobs Sandra, Karremann Michael, Kattamis Antonis, Kebudi Rejin, Kortmann Rolf-Dieter, Kwiecien Robert, Massimino Maura, Mastronuzzi Angela, Miele Evelina, Morana Giovanni, Noack Claudia M, Pentikainen Virve, Perwein Thomas, Pfister Stefan M, Pietsch Torsten, Roka Kleoniki, Rossi Sabrina, Rutkowski Stefan, Schiavello Elisabetta, Seidel Clemens, Štěrba Jaroslav, Sturm Dominik, Sumerauer David, Tacke Anna, Temelso Sara, Valentini Chiara, van Vuurden Dannis, Varlet Pascale, Veldhuijzen van Zanten Sophie E M, Vinci Maria, von Bueren André O, Warmuth-Metz Monika, Wesseling Pieter, Wiese Maria, Wolff Johannes E A, Zamecnik Josef, Morales La Madrid Andrés, Bison Brigitte, Gielen Gerrit H, Jones David T W, Jones Chris, Kramm Christof M
Abstract excerpt
BACKGROUND: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. METHODS: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization. RESULTS: Median overall survival (OS) was 15.5 months...
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