High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts.

doi:10.1093/neuonc/noaa024

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Article

High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts.

Neuro-oncology - 17 Aug 2020

Roux Alexandre, Pallud Johan, Saffroy Raphaël, Edjlali-Goujon Myriam, Debily Marie-Anne, Boddaert Nathalie, Sanson Marc, Puget Stéphanie, Knafo Steven, Adam Clovis, Faillot Thierry, Cazals-Hatem Dominique, Mandonnet Emmanuel, Polivka Marc, Dorfmüller Georges, Dauta Aurélie, Desplanques Mathilde, Gareton Albane, Pages Mélanie, Tauziede-Espariat Arnault, Grill Jacques, Bourdeaut Franck, Doz François, Dhermain Frédéric, Mokhtari Karima, Chretien Fabrice, Figarella-Branger Dominique, Varlet Pascale

Abstract excerpt

BACKGROUND: Considering that pediatric high-grade gliomas (HGGs) are biologically distinct from their adult counterparts, the objective of this study was to define the landscape of HGGs in adolescents and young adults (AYAs). METHODS: We performed a multicentric retrospective study of 112 AYAs from adult and pediatric Ile-de-France neurosurgical units, treated between 1998 and 2013 to analyze their...

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PMID: 32025728
DOI: 10.1093/neuonc/noaa024
PMCID: PMC7594566

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