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Article

Mutations in SARS-CoV-2 spike protein identified by mass spectrometry based phylogenetics and their structural and functional consequences.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Wright Matthew, Downard Kevin M

Abstract excerpt

The structural and functional consequences of mutations located throughout the S1 and S2 subunit domains of spike protein among omicron and D614G-mutant originating forms of the SARS-CoV-2 virus are examined. These structural mutations were identified by a mass-based phylogenetics approach. The T95I mutation, located in the S1 N-terminal domain, and the T547K mutation of the receptor-binding domain both help to...

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PMID: 41587096
DOI: 10.1080/07391102.2025.2609686

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