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Article

Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants.

Scientific reports - 20 May 2022

da Costa Clauber Henrique Souza, de Freitas Camila Auad Beltrão, Alves Cláudio Nahum, Lameira Jerônimo

Abstract excerpt

The severe acute respiratory syndrome (SARS) coronavirus 2 (CoV-2) variant Omicron spread more rapid than the other variants of SARS-CoV-2 virus. Mutations on the Spike (S) protein receptor-binding domain (RBD) are critical for the antibody resistance and infectivity of the SARS-CoV-2 variants. In this study, we have used accelerated molecular dynamics (aMD) simulations and free energy calculations to present a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35595778
DOI: 10.1038/s41598-022-12479-9
PMCID: PMC9121086

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