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Article

Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase.

Acta neuropathologica communications - 25 Jan 2016

Tokuda Eiichi, Brännström Thomas, Andersen Peter M, Marklund Stefan L

Abstract excerpt

INTRODUCTION: The motor system is selectively vulnerable to mutations in the ubiquitously expressed aggregation-prone enzyme superoxide dismutase-1 (SOD1). RESULTS: Autophagy clears aggregates, and factors involved in the process were analyzed in multiple areas of the CNS from human control subjects (n = 10) and amyotrophic lateral sclerosis (ALS) patients (n = 18) with or without SOD1 mutations. In control...

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Identifiers

PMID: 26810478
DOI: 10.1186/s40478-016-0274-y
PMCID: PMC4727314

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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