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Article

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

Molecular medicine (Cambridge, Mass.) - 25 Oct 2024

Martínez Pablo, Silva Mónica, Abarzúa Sebastián, Tevy María Florencia, Jaimovich Enrique, Constantine-Paton Martha, Bustos Fernando J, van Zundert Brigitte

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of MNs. Although MNs innervate muscle fibers and ALS is characterized by the early disruption of the neuromuscular...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39455931
DOI: 10.1186/s10020-024-00942-4
PMCID: PMC11505737

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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