Article
Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.
The Journal of biological chemistry - 31 May 2013
Basso Manuela, Pozzi Silvia, Tortarolo Massimo, Fiordaliso Fabio, Bisighini Cinzia, Pasetto Laura, Spaltro Gabriella, Lidonnici Dario, Gensano Francesco, Battaglia Elisa, Bendotti Caterina, Bonetto Valentina
Abstract excerpt
Amyotrophic lateral sclerosis is the most common motor neuron disease and is still incurable. The mechanisms leading to the selective motor neuron vulnerability are still not known. The interplay between motor neurons and astrocytes is crucial in the outcome of the disease. We show that mutant copper-zinc superoxide dismutase (SOD1) overexpression in primary astrocyte cultures is associated with decreased levels...
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