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Article

Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells.

PloS one - 1 Jan 2017

Pokrishevsky Edward, Hong Ran Ha, Mackenzie Ian R, Cashman Neil R

Abstract excerpt

Mutant Cu/Zn superoxide dismutase (SOD1) can confer its misfolding on wild-type SOD1 in living cells; the propagation of misfolding can also be transmitted between cells in vitro. Recent studies identified fluorescently-tagged SOD1G85R as a promiscuous substrate that is highly prone to aggregate by a variety of templates, in vitro and in vivo. Here, we utilized several SOD1-GFP reporter proteins with G37R, G85R,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28877271
DOI: 10.1371/journal.pone.0184384
PMCID: PMC5587256

Genes

SOD1

Variants

Provenance

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