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Enhanced d-mannose production by rational engineering of cellobiose 2-Epimerase.

Bioresource technology - 1 Apr 2026

Wang Sheng, Lu Mengwei, Liu Tianyu, Li Zhihao, Huang Yan, Yan Zhengfei, Liu Zhanzhi, Wu Jing, Xia Wei

Abstract excerpt

The conversion of glucose to prepare mannose is a biotransformation pathway with great economic value and industrial prospects. The cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus (CsCE) can catalyze this reaction process at relatively high temperatures, exhibiting advantages such as high substrate solubility and resistance to microbial contamination, but it is unfortunately limited by a low...

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PMID: 41577057
DOI: 10.1016/j.biortech.2026.134059

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