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Article

Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

14 Nov 2018

Abstract excerpt

Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer; however, little is known about genetic heterogeneity in these lesions. The objective of this study was to characterize genetic heterogeneity in IPMNs at the single-cell level. We isolated single cells from fresh tissue from ten IPMNs, followed by whole genome amplification and targeted next-generation sequencing of pancreatic...

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PMID: 30430578
DOI: 10.1002/path.5194

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