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Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration

10 Dec 2010

Abstract excerpt

Telomeres comprise long tracts of double-stranded TTAGGG repeats that extend for 9-15 kb in humans. Telomere length is maintained by telomerase, a specialized ribonucleoprotein that prevents the natural ends of linear chromosomes from undergoing inappropriate repair, which could otherwise lead to deleterious chromosomal fusions. During the development of cardiovascular tissues, telomerase activity is strong but...

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PMID: 21148539
DOI: 10.1093/eurheartj/ehq450

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