Telomere 3’-overhang attrition and persistent telomeric DNA damage response in failing human hearts

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Telomere homeostasis is critical for normal cellular and organ function, and its dysregulation is implicated in aging and chronic diseases. Although telomere length (TL) is critical for normal telomere function, its functional status can also be altered by many other factors. The organization and protective status of telomere in failing human heart (FHH) remains incompletely...

Topics

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• Cardiomyopathy, Dilated
• Cardiomyopathy, Hypertrophic, Familial
• Cell Division
• Induced Pluripotent Stem Cells
• Muscle Proteins
• Mutation
• Telomere Shortening
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

7392de70-d4c2-58cc-9f8d-664b17701230

DOI

10.1101/2025.08.12.669993