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ILT4 and its R20H variant as marker of poor prognosis in Spanish patients with colorectal cancer.

Human immunology - 1 Mar 2026

Fernández-Uría Sandra, Vaquero-Yuste Christian, Álvarez-González Elena, Del Pueblo Cristina Sánchez, Suárez-Solís María Luisa, Mugüerza-Huguet José María, Arnaiz-Villena Antonio, Martín-Villa José Manuel, Juarez Ignacio

Abstract excerpt

BACKGROUND: Immune checkpoint blockade is proving beneficial for cancer treatment by stimulating the anti-tumor immune response. However, the lack of success in certain cancer types encourages the research of new potential targets. ILT4 (Immunoglobulin-like transcript 4) is a transmembrane protein that binds with high affinity to HLA-G molecules present on tumor cells, modulating responses mediated by monocytes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41570702
DOI: 10.1016/j.humimm.2026.111670

Genes

LILRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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