Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis.

doi:10.1371/journal.pmed.1003292

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Article

Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis.

PLoS medicine - 1 Sept 2020

Sanz-Pamplona Rebeca, Melas Marilena, Maoz Asaf, Schmit Stephanie L, Rennert Hedy, Lejbkowicz Flavio, Greenson Joel K, Sanjuan Xavier, Lopez-Zambrano Maria, Alonso M Henar, Qu Chenxu, McDonnell Kevin J, Idos Gregory E, Vignali Marissa, Emerson Ryan, Fields Paul, Guinó Elisabet, Santos Cristina, Salazar Ramon, Robins Harlan S, Rennert Gad, Gruber Stephen B, Moreno Victor

Abstract excerpt

BACKGROUND: Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and the quality of the host immune response in the tumor microenvironment have been reported to have an important role in tumorigenesis and an inverse association with...

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PMID: 32970670
DOI: 10.1371/journal.pmed.1003292
PMCID: PMC7514069

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