Article
Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2020
Neumeyer Sonja, Hua Xinwei, Seibold Petra, Jansen Lina, Benner Axel, Burwinkel Barbara, Halama Niels, Berndt Sonja I, Phipps Amanda I, Sakoda Lori C, Schoen Robert E, Slattery Martha L, Chan Andrew T, Gala Manish, Joshi Amit D, Ogino Shuji, Song Mingyang, Herpel Esther, Bläker Hendrik, Kloor Matthias, Scherer Dominique, Ulrich Alexis, Ulrich Cornelia M, Win Aung K, Figueiredo Jane C, Hopper John L, Macrae Finlay, Milne Roger L, Giles Graham G, Buchanan Daniel D, Peters Ulrike, Hoffmeister Michael, Brenner Hermann, Newcomb Polly A, Chang-Claude Jenny
Abstract excerpt
BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and therefore variants in genes related to Treg differentiation and function could be associated with colorectal cancer prognosis. METHODS: In a prospective German cohort of...
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