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Article

Genetic variations in the CTLA-4 immune checkpoint pathway are associated with colon cancer risk, prognosis, and immune infiltration via regulation of IQCB1 expression.

Archives of toxicology - 1 Jun 2021

Ben Shuai, Zhu Qiuyuan, Chen Silu, Li Shuwei, Du Mulong, Xin Junyi, Chu Haiyan, Zhang Zhengdong, Wang Meilin

Abstract excerpt

The programmed cell death-1 (PD-1)/cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) immune checkpoint pathways serve as targets of immunotherapy for colorectal cancer. However, the associations between genetic variations in these pathways and colorectal cancer risk, prognosis, and immune status remain unclear. The associations between single-nucleotide polymorphisms (SNPs) and colorectal cancer risk and...

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Identifiers

PMID: 33847778
DOI: 10.1007/s00204-021-03040-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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