Article
Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities.
Human genetics - 22 Jan 2026
Durodoye Razaq O, Ciesielski Timothy H, Benchek Penelope, Bartlett Jacquelaine, Zhu Xiaofeng, Liu Shiying, Naj Adam, Kunkle Brian, Schellenberg Gerard D, Mayeux Richard, Farrer Lindsay, Wang Li-San, Pericak-Vance Margaret A, Rajabli Farid, Tosto Giuseppe, Haines Jonathan L, Bush William S, Williams Scott M
Abstract excerpt
APOE’s ε4 haplotype (APOE4) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4-LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic),...
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