Article
ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2025
Akgun Bilcag, Gulyayev Alexander V, Coker Motunrayo, Hamilton-Nelson Kara L, Olalusi Oladotun, Adams Larry D, Akinwande Kazeem, Whitehead Patrice G, Diala Samuel, Ogunronbi Mayowa, Laux Renee A, Akpalu Albert, Starks Takiyah D, Sarfo Fred S, Chavez Jenny, Lwere Kamada, Beecham Gary W, Akinyemi Joshua O, Obiako Reginald, Ndetei David, Caban-Holt Allison, Ayele Biniyam, Ogrocki Paula, Griswold Anthony J, Zaman Andrew F, Mena Pedro R, Martinez Izri M, Blanton Susan H, Okubadejo Njideka, Damasceno Albertino, Kalaria Rajesh, Cuccaro Michael L, McInerney Katalina F, Bush William S, Kunkle Brian W, Ogunniyi Adesola, Vance Jeffery M, Akinyemi Rufus O, Haines Jonathan L, Reitz Christiane, Byrd Goldie S, Rajabli Farid, Pericak-Vance Margaret A
Abstract excerpt
INTRODUCTION: Apolipoprotein E (APOE) and ABCA7 genes are among the strongest heritable risk factors for Alzheimer's disease (AD) in African-ancestry (AA) populations. APOE 𝜀4 affects both risk and age at onset (AAO), with lower risk in AA populations. This study evaluates the independent and interactive effects of the AA-specific ABCA7 frameshift deletion and APOE 𝜀4 allele on AAO. METHODS: We analyzed 3510 AA...
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