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Article

ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

12 Jan 2023

Abstract excerpt

Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal and synaptic loss. Apolipoprotein E (ApoE)-mediated neuroinflammation is involved in the progression of tau-mediated neurodegeneration, and emerging evidence suggests that the gut microbiota regulates neuroinflammation in an APOE genotype-dependent manner....

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PMID: 36634180
DOI: 10.1126/science.add1236

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