Article

Regulated conformational transitions in seipin define a functional ER–lipid droplet interface

2026-06-23

Abstract excerpt

Lipid droplets (LDs) are key organelles in cellular lipid homeostasis that form at the endoplasmic reticulum (ER) through a sequence of membrane rearrangements. While seipin emerged as an essential protein complex for LD biogenesis, how seipin-mediated LD formation proceeds beyond the initial step of neutral lipid nucleation remains unknown. Using a combination of in vitro and in-cell cryogenic electron microscop...

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Literature Corpus work: f85693d3-8a33-5ac4-8813-005d2d4bed93
DOI: 10.64898/2026.06.22.733769

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