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Article

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis.

eLife - 13 Apr 2016

Tang Shaogeng, Buchkovich Nicholas J, Henne W Mike, Banjade Sudeep, Kim Yun Jung, Emr Scott D

Abstract excerpt

The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and polymeric state (Tang et al., 2015). However, how ESCRT-III activation is coordinated by the upstream ESCRT components at endosomes remains unclear. Here, we...

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Share to Cell Membrane
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

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Share to Protein Structure, Secondary

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Identifiers

PMID: 27074665
DOI: 10.7554/eLife.15507
PMCID: PMC4865371

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