Article
High-Speed Atomic Force Microscopy Reveals Disordered Region-Mediated Structural Plasticity of Anaplastic Lymphoma Kinase Fusion Proteins Induced by Inhibitors.
ACS nano - 3 Feb 2026
Han Xujun, Kodera Noriyuki, Yilmaz Neval, Sakai Katsuya, Arai Sachiko, Li Borui, Imamura Ryu, Voon Dominic Chih-Cheng, Fukuda Koji, Nanjo Shigeki, Flechsig Holger, Mano Hiroyuki, Matsumoto Kunio, Yano Seiji
Abstract excerpt
EML4-ALK is a key oncogenic driver in lung cancer, but variant-specific chemoresistance limits the efficacy of current ALK inhibitors. Because the N-terminus contains an intrinsically disordered region (IDR), how ALK inhibitors affect the structure and dynamics of full-length EML4-ALK remains unclear. Here, using high-speed atomic force microscopy (HS-AFM), we visualize the overall structures of three full-length...
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