Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A.

The Journal of biological chemistry - 1 Mar 2024

Carrington Glenn, Fatima Uzrama, Caramujo Ines, Lewis Tarek, Casas-Mao David, Peckham Michelle

Abstract excerpt

Kinesin-1 is a microtubule motor that transports cellular cargo along microtubules. KIF5A is one of three kinesin-1 isoforms in humans, all of which are autoinhibited by an interaction between the motor and an IAK motif in the proximal region of the C-terminal tail. The C-terminal tail of KIF5A is ∼80 residues longer than the other two kinesin-1 isoforms (KIF5B and KIF5C) and it is unclear if it contributes to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exons
Share to Kinesins
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 38309508
DOI: 10.1016/j.jbc.2024.105713
PMCID: PMC10907169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A.PMID 38309508Read ↗

A Multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5ASemantic proximity Read ↗

Cryo-EM Unveils the Processivity Mechanism of Kinesin KIF1A and the Impact of its Pathogenic Variant P305LSemantic proximity Read ↗

Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L.Semantic proximity Read ↗

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.Semantic proximity Read ↗

Pathogenic KIF1A R350 Variants Disrupt A Conserved Kinesin-Tubulin Salt BridgeSemantic proximity Read ↗

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-bindingSemantic proximity Read ↗

Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge.Semantic proximity Read ↗

Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders.Semantic proximity Read ↗

One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases.Semantic proximity Read ↗

ALS-linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain of functionSemantic proximity Read ↗

A Highly Conserved 3 <sub>10</sub> -Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human HealthSemantic proximity Read ↗

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN networkSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.