Article

A Multiscale approach reveals the molecular architecture of the autoinhibited kinesin KIF5A

2024-01-18

Abstract excerpt

Kinesin-1 is a microtubule motor that transports cellular cargo along microtubules. KIF5A is one of three kinesin-1 isoforms in humans, all of which are autoinhibited by an interaction between the motor and an IAK motif in the proximal region of the C-terminal tail. The C-terminal tail of KIF5A is ∼80 residues longer than the other two kinesin-1 isoforms (KIF5B and KIF5C) and it is unclear if it contributes to aut...

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Literature Corpus work: c6aa2a7e-56f4-5b31-a35f-cfd5618dc4c4
DOI: 10.1101/2024.01.18.576271

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