Article
Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence.
Journal of visualized experiments : JoVE - 30 Dec 2025
Chin Shao-I, Zeng Zi-Min, Chen Sih-Tong, Lin Kuan-Yu, Chen Jing-Yan, Cheng Yi-Ting, Wang Hsiao-Hsuan, Wu Kuan-Yo, Chen Chia-Chi, Cai Bi-He
Abstract excerpt
The tumor suppressor p53, encoded by the TP53 gene, plays a central role in maintaining genomic stability. TP53 mutations, particularly hotspot variants, are found in approximately 50% of human cancers and may lead to the loss of tumor-suppressive functions or the acquisition of gain-of-function properties, including aggregation into prion-like structures. In this study, we assessed the aggregation tendency of...
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