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Article

First-order rate-determining aggregation mechanism of p53 and its implications.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Wang GuoZhen, Fersht Alan R

Abstract excerpt

Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C....

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Identifiers

PMID: 22869710
DOI: 10.1073/pnas.1211557109
PMCID: PMC3427100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22869710-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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