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Article

Effects of ABC transporter polymorphism on the pharmacokinetics of pentoxifylline and its active metabolites in healthy Chinese subjects.

European journal of clinical pharmacology - 19 Jan 2026

Guo Lingfang, Sun Xue, Qiu Bo, Bai Wanjun, Du Yabin, Song Haojing

Abstract excerpt

PURPOSE: The objective of this study was to evaluate the influence of genetic polymorphisms in drug transporters on the pharmacokinetics of pentoxifylline (PTX) and its key active metabolites in a healthy Chinese population. SUBJECTS AND METHODS: Forty-six healthy Chinese volunteers were enrolled and took oral administration of 400 mg pentoxifylline. Plasma concentrations of PTX and its active metabolites (M1 and...

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Identifiers

PMID: 41553547
DOI: 10.1007/s00228-026-03993-0

Genes

ABCB1
ABCC2
ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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