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Article

Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Oh Eun Sil, Kim Choon Ok, Cho Sung Kweon, Park Min Soo, Chung Jae-Yong

Abstract excerpt

Pitavastatin, a 3-hydroxyl-3-methylglutaryl-coenzyme A reductase inhibitor is distributed to the liver, a target organ of action and excreted mainly into the bile. To investigate the impact of influx (OATP1B1) and efflux (MRP2, BCRP) transporter alleles on its disposition, the pharmacokinetic (PK) parameters were compared among the following groups: SLCO1B1 (*15 carrier and non-carrier), ABCC2 (G1249A, C3972T,...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver-Specific Organic Anion Transporter 1

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Source

Identifiers

PMID: 23007012
DOI: 10.2133/dmpk.dmpk-12-rg-068

Genes

ABCC2
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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