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Article

Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects.

Clinical pharmacology in drug development - 1 Jan 2021

Sun Lu-Ning, Sun Guo-Xian, Yang Yu-Qing, Shen Ye, Huang Feng-Ru, Xie Li-Jun, Cheng Juan, Zhang Hong-Wen, Zhang Xue-Hui, Liu Yun, Wang Yong-Qing

Abstract excerpt

Sitafloxacin, a new fluoroquinolone, has strong antibacterial activity. We evaluated the effects of sitafloxacin granules in single-dose and multidose cohorts and the effects of ABCB1, UGT1A1, and UGT1A9 genetic polymorphisms on the pharmacokinetics (PK) of sitafloxacin in healthy subjects. The single-dose study included 3 fasted cohorts receiving 50, 100, and 200 mg of sitafloxacin granules and 1 cohort...

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Identifiers

PMID: 32687695
DOI: 10.1002/cpdd.848
PMCID: PMC7818398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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