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Article

An integrated pharmacokinetic/pharmacogenomic analysis of ABCB1 and SLCO1B1 polymorphisms on edoxaban exposure.

The pharmacogenomics journal - 1 Jan 2018

Vandell A G, Lee J, Shi M, Rubets I, Brown K S, Walker J R

Abstract excerpt

Edoxaban and its low-abundance, active metabolite M4 are substrates of P-glycoprotein (P-gp; MDR1) and organic anion transporter protein 1B1 (OATP1B1), respectively, and pharmacological inhibitors of P-gp and OATP1B1 can affect edoxaban and M4 pharmacokinetics (PK). In this integrated pharmacogenomic analysis, genotype and concentration-time data from 458 healthy volunteers in 14 completed phase 1 studies were...

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Source

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Identifiers

PMID: 27897269
DOI: 10.1038/tpj.2016.82
PMCID: PMC5817390

Genes

ABCB1

Variants

rs1045642
rs1045642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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