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CYP2C9*3(1075A > C), ABCB1 and SLCO1B1 genetic polymorphisms and gender are determinants of inter-subject variability in pitavastatin pharmacokinetics.

Die Pharmazie - 1 Mar 2013

Zhou Quan, Chen Qiu-Xia, Ruan Zou-Rong, Yuan Hong, Xu Hui-Min, Zeng Su

Abstract excerpt

A pharmacokinetics study was conducted in 12 Chinese volunteers following a single dose of 1 mg, 2 mg and 4 mg of pitavastatin calcium in an open-label, randomized, three-period crossover design. Plasma concentrations of pitavastatin acid and pitavastatin lactone were determined by a HPLC method. Single-nucleotide polymorphisms (SNPs) in ABCB1, ABCG2, SLCO1B1, CYP2C9 and CYP3A5 were determined by TaqMan (MGB)...

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Identifiers

PMID: 23556337

Genes

ABCB1
ABCG2

Variants

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