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Article

Unveiling novel susceptibility genes for kidney stone disease by a cross-tissue transcriptome-wide association study.

World journal of urology - 18 Jan 2026

Sun Xiqiao

Abstract excerpt

PURPOSE: Kidney stone disease has a strong but incompletely understood genetic component. Traditional genome-wide association studies (GWAS) mostly uncover non-coding variants whose target genes remain ambiguous. Integrating transcriptome-wide association studies (TWAS) with post-GWAS analyses can pinpoint the genes through which these variants act. METHOD: Using GWAS summary statistics from 12,999 cases and...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Kidney Calculi
Transcriptome

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41549149
DOI: 10.1007/s00345-025-06070-w

Genes

GCAT
NLRC4
UGT8
USP40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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