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Article

Integrative multi-layer genetic analysis identifies novel susceptibility genes for urolithiasis.

Urolithiasis - 12 Feb 2026

Zhu Guangqiang, Tan Chunlin, Li Yugen

Abstract excerpt

Urolithiasis is a complex disease influenced by genetic and metabolic factors. Although genome-wide association studies (GWAS) have identified susceptibility loci, the causal genes and mechanisms remain unclear. This study aimed to identify genes whose genetically regulated expression contributes to urolithiasis risk and clarify their potential biological roles. We integrated two independent European-ancestry...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41677905
DOI: 10.1007/s00240-026-01951-0

Genes

GCAT
UGT8

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