Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Integrative multi-layer genetic analysis identifies novel susceptibility genes for urolithiasis.

Urolithiasis - 12 Feb 2026

Zhu Guangqiang, Tan Chunlin, Li Yugen

Abstract excerpt

Urolithiasis is a complex disease influenced by genetic and metabolic factors. Although genome-wide association studies (GWAS) have identified susceptibility loci, the causal genes and mechanisms remain unclear. This study aimed to identify genes whose genetically regulated expression contributes to urolithiasis risk and clarify their potential biological roles. We integrated two independent European-ancestry...

Topics

Humans
Urolithiasis
Genetic Predisposition to Disease
Genome-Wide Association Study
Quantitative Trait Loci
Glucuronosyltransferase
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41677905
DOI: 10.1007/s00240-026-01951-0

Genes

GCAT
UGT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative multi-layer genetic analysis identifies novel susceptibility genes for urolithiasis.PMID 41677905Read ↗

Unveiling novel susceptibility genes for kidney stone disease by a cross-tissue transcriptome-wide association study.Semantic proximity Read ↗

Genetic susceptibility of urolithiasis: comprehensive results from genome-wide analysis.Semantic proximity Read ↗

Identification of potential pathogenic genes for urolithiasis through multi-omics Mendelian randomization analysis.Semantic proximity Read ↗

Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese PopulationSemantic proximity Read ↗

Integrated multi-omics analyses reveal causal insights into the molecular landscape of urologic cancersSemantic proximity Read ↗

Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis.Semantic proximity Read ↗

GWAS identifies nine nephrolithiasis susceptibility loci related with metabolic metabolic and crystallization pathwaysSemantic proximity Read ↗

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.Semantic proximity Read ↗

Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.Semantic proximity Read ↗

Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Semantic proximity Read ↗

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in goutSemantic proximity Read ↗

Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene FXN as a hypothesis-generating candidate for nephrolithiasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.