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Identification of potential pathogenic genes for urolithiasis through multi-omics Mendelian randomization analysis.

Urolithiasis - 16 Dec 2024

Yan Kun, Li Caogang, Chen Bohong, Tao Yifang, Zhang Dong, Zhang Peng

Abstract excerpt

Urolithiasis, a common urological disorder affecting about 10% of the global population, is known for its high recurrence rate, yet its genetic mechanisms remain poorly understood. This study aimed to fill this gap by identifying potential pathogenic genes associated with urolithiasis using a multi-omics Mendelian randomization approach. We conducted a comprehensive analysis that integrated genome-wide...

Topics

Humans
Urolithiasis
Mendelian Randomization Analysis
Genome-Wide Association Study
Quantitative Trait Loci
DNA Methylation
Bayes Theorem
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39680155
DOI: 10.1007/s00240-024-01675-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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