Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.

Nature communications - 18 Nov 2023

Hao Xingjie, Shao Zhonghe, Zhang Ning, Jiang Minghui, Cao Xi, Li Si, Guan Yunlong, Wang Chaolong

Abstract excerpt

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We performed a large genome-wide association study (GWAS) meta-analysis for KSD to date, including 720,199 individuals with 17,969 cases in European population. We identified 44 susceptibility loci, including 28 novel loci. Cell type-specific analysis pinpointed the proximal tubule as the most relevant cells where...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Loci
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Ion Transport and Channel Regulation

Share to Kidney Calculi

Share to Kidney Stones and Urolithiasis Treatments

Share to Pediatric Urology and Nephrology Studies

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 37980427
DOI: 10.1038/s41467-023-43400-1
PMCID: PMC10657403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.PMID 37980427Read ↗

Genetic susceptibility to kidney stone disease: unveiling pathogenesis and potential therapeutic targets.Semantic proximity Read ↗

Kidney stone biology: insights from geneticsSemantic proximity Read ↗

Genetics of kidney stone disease-Polygenic meets monogenic.Semantic proximity Read ↗

Progress in Understanding the Genetics of Calcium-Containing NephrolithiasisSemantic proximity Read ↗

Unveiling novel susceptibility genes for kidney stone disease by a cross-tissue transcriptome-wide association study.Semantic proximity Read ↗

Genetic variants of calcium and vitamin D metabolism in kidney stone disease.Semantic proximity Read ↗

Genetics of kidney stones and the role of genetic testing in prevention: a guide for urologistsSemantic proximity Read ↗

Genetic variants of calcium and vitamin D metabolism in kidney stone diseaseSemantic proximity Read ↗

Genetic variants predisposing to an increased risk of kidney stone diseaseSemantic proximity Read ↗

Genetics of common complex kidney stone disease: insights from genome-wide association studiesSemantic proximity Read ↗

Genetic variants predisposing to increased risk of kidney stone diseaseSemantic proximity Read ↗

Genetic Insights Into Nephrolithiasis and Renal Cancer Predisposition: Precision Medicine in Genes, Diagnosis, and Therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.