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A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort

19 May 2025

Abstract excerpt

Background/Objectives: Diabetic kidney disease (DKD) is a common diabetic complication, driven by a multifactorial pathogenesis that includes various genetic components. However, the precise causative genes and their underlying biological pathways remain poorly understood. Methods: We performed a cross-tissue transcriptome-wide association study (TWAS) of DKD using expression quantitative trait loci (eQTL) data...

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Share to Chronic Kidney Disease and Diabetes
Share to Epigenetics and DNA Methylation
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PMID: 40427057
DOI: 10.3390/biomedicines13051231

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