Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to kidney stone disease: unveiling pathogenesis and potential therapeutic targets.

The Journal of clinical investigation - 1 Aug 2025

Li Shiwei, Wang Xuemei, Liu Ming

Abstract excerpt

Kidney stone disease (KSD) arises from a complex interplay of genetic predisposition, diet, metabolic disorders, and other environmental factors. In this issue of the JCI, Lovegrove et al. report a large GWAS that identifies 71 loci associated with an increased risk of KSD. Through an integrative approach combining Mendelian randomization and functional validation, they emphasize the roles of DGKD, SLC34A1, and...

Topics

Join the communities discussing this publication.

Calcium
Genetic Predisposition to Disease
Genome-Wide Association Study
Kidney Calculi
Kidney Stones and Urolithiasis Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parathyroid Disorders and Treatments

Vitamin D3 24-Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 40759569
DOI: 10.1172/JCI195624
PMCID: PMC12321377

Genes

CYP24A1
DGKD
SLC34A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to kidney stone disease: unveiling pathogenesis and potential therapeutic targets.PMID 40759569Read ↗

Genetic variants predisposing to increased risk of kidney stone diseaseSemantic proximity Read ↗

Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Semantic proximity Read ↗

Genetic variants of calcium and vitamin D metabolism in kidney stone disease.Semantic proximity Read ↗

Genetic variants predisposing to an increased risk of kidney stone diseaseSemantic proximity Read ↗

Genetic variants of calcium and vitamin D metabolism in kidney stone diseaseSemantic proximity Read ↗

Genetics of kidney stones and the role of genetic testing in prevention: a guide for urologistsSemantic proximity Read ↗

Kidney stone biology: insights from geneticsSemantic proximity Read ↗

Role of Genetic Testing in Kidney Stone Disease: A Narrative Review.Semantic proximity Read ↗

Genetics of common complex kidney stone disease: insights from genome-wide association studiesSemantic proximity Read ↗

Genetics of kidney stone disease-Polygenic meets monogenic.Semantic proximity Read ↗

Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease.Semantic proximity Read ↗

Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.